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(c) Sweat

(d) Hair

2.2 Under what circumstances can the different types of specimens be collected?

Recommended reasons for specimen type selected are as follows:

Type of Specimen Reason For Test

Urine Pre-employment, random, reasonable suspicion/cause,

post accident, return to duty, follow-up

Oral Fluid reasonable suspicion/cause, post accident

Sweat Return to duty, follow-up

Hair Pre-employment, random, follow-up

Subpart C – Drugs

3.1 For which drugs can a specimen be tested?

The Executive Order 12564 defines “illegal drugs” as those included in Schedule I or II of the Controlled Substances Act (CSA), but not when used pursuant to a valid prescription or when used as otherwise authorized by law. Federal agency drug testing programs must test all specimens for marijuana and cocaine use and may test for use of opiates, amphetamines, and phencyclidine.

3.2 Can a specimen be tested for additional drugs?

(a) Reasonable suspicion/cause, or post accident specimens may be tested for any drug listed in Schedule I or II of the CSA.

(b) A Federal agency covered by these Guidelines must petition the Secretary in writing for approval to routinely test for any drug class not listed in section 3.1. Such approval shall be limited to the use of the appropriate science and technology and shall not otherwise limit agency discretion to test for any drug tested under paragraph (a) of this section.

3.3 Can a specimen be used for other purposes?

(a) Specimens collected pursuant to these Guidelines may be used to test only for those drugs included in the Agency workplace drug testing program. They may not be used to conduct any other analysis or test unless otherwise authorized by the Guidelines.

(b) A specimen that tests negative by initial or confirmatory testing may, however, be pooled for use in a laboratory’s internal quality control program.

(c) These Guidelines are not intended to prohibit any Federal agency specifically authorized by law to test for additional classes of drugs in its workplace drug testing program.

3.4What is the cutoff concentration for each drug by type of specimen collected?

Urine

Initial Test Cutoff Concentration

(ng/mL)

Marijuana metabolites………..50

Cocaine metabolites…………..150

Opiate metabolites……………..2000

Phencyclidine……………………25

Amphetamines………………….500 Screening must significantly cross-react w/MDMA (Roughly equal cross-reactivity)

Confirmatory Test Cutoff Concentration

(ng/mL)

Marijuana metabolite1…………..15

Cocaine metabolite2……………..100

Opiates

Morphine……………………….?..2000

Codeine…………………………?…2000

6-acetylmorphine ……………?..10

Phencyclidine………………….?..25

Amphetamines

d-Amphetamine………………..150 – 250

d-Methamphetamine3………..150 – 250

MDMA…………………..????..150 – 250

MDA………………………….???..150 – 250

MDEA………………………..???.150 – 250

1 Delta-9-tetrahydrocannabinol-9-carboxylic acid

2 Benzoylecgonine

3 Specimen must also contain Amphetamine at a concentration * 100 ng/mL

Hair

Initial Test Cutoff Concentration

(pg/mg)

Marijuana metabolites…………1.0

Cocaine metabolites……………500

Opiate metabolites……………..200

Phencyclidine…………………….300

Amphetamines……………………500 Screening must cross-react w/MDMA

Confirmatory Test Cutoff Concentration

(pg/mg)

Marijuana metabolite1……………0.05

Cocaine metabolite2………………100

Cocaine……………………………….1000

BE/COC ratio *= 0.1

Opiates

Morphine………………………….200

Codeine……………………………200

6-acetylmorphine ……………..200

Hair 6-AM rule (TO BE DETERMINED)

Phencyclidine…………………..300

Amphetamines

d-Amphetamine…………….?300

d-Methamphetamine…..??300

Hair amp rule………????50

MDMA

MDA

MDEA

1 Delta-9-tetrahydrocannabinol-9-carboxylic acid

2 Benzoylecgonine

Sweat

Initial Test Cutoff Concentration Target Analyte

(ng/ 2.5 mL eluate)

Marijuana metabolites…………1.5THC

Cocaine metabolites……………10Benzoylecgonine

Opiate metabolites……………..10Morphine

Phencyclidine……………………7.5Phencyclidine

Amphetamines………………….10d-Methamphetamine

(Amp screening must cross-react w/MDMA)

Confirmatory Test Cutoff Concentration

(ng/2.5 mL eluate)

THC parent drug……………………..0.5

Cocaine parent drug……………..?10

Cocaine metabolite2……………?.10

Opiates

Morphine………………………….10

Codeine……………………………10

6-acetylmorphine ……………..10

Phencyclidine……………………..7.5

Amphetamines

d-Amphetamine…………………10

d-Methamphetamine3…………10

MDMA

MDA

MDEA

2 Benzoylecgonine

3 Specimen must also contain Amphetamine at a

concentration * (TO BE DETERMINED) ng/mL

Oral Fluid

Initial Test Cutoff Concentration

(ng/mL)

Marijuana metabolites…………4

Cocaine

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